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Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease

The original description of mammalian aggresomes (focused in cultured CHO and HEK cells) defined multiple aggresome features, including prominent juxtanuclear concentration of aggregates with distinct localization from Golgi and lysosomes, association with intermediate filaments under proteostress conditions (aggregate-prone protein over-expression or inhibition of the proteasome), colocalization with ubiquitinated and heterogeneous cargo, and requirements for microtubule and dynein motor integrity for biogenesis 3

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